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News & Events

Controlling contractile instabilities in the actomyosin cortex

掲載日:
講演会
開催日:
日時 2月28日(火) 16:00–18:00
場所 北海道大学電子科学研究所(北キャンパス総合研究棟5号館) セミナー室1-2
講演者 西川 正俊 助教
所属等 法政大学 生命機能学科
タイトル Controlling contractile instabilities in the actomyosin cortex
概要

The actomyosin cell cortex is an active contractile material for driving cell- and tissue morphogenesis. The cortex has a tendency to form a pattern of myosin foci, which is a signature of potentially unstable behavior. How a system that is prone to such instabilities can reliably drive morphogenesis remains an outstanding question. Here we report that in Caenorhabditis elegans zygote, feedback between active RhoA and myosin induces a contractile instability in the cortex. We discover that an independent RhoA pacemaking oscillator controls this instability, generating a pulsatory pattern of myosin foci and preventing the collapse of cortical material into a few dynamic contracting regions. Our work reveals how contractile instabilities that are natural to occur in mechanically active media can be biochemically controlled in order to robustly drive morphogenetic events.

連絡先 佐藤 勝彦

北海道大学 電子科学研究所 附属社会創造数学研究センター 知能数理研究分野
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