|日時||2018年7月18日 16:00 – 17:30|
|所属||Department of Biological Sciences, National University of Singapore, Mechanobiology Institute, National University of Singapore|
|講演題目||Tissue mechanobiology: Mechanical forces behind tissue morphogenesis|
Our research is focused on tissue dynamics in fly embryo during the development and in engineered tissue.
We are interested in two particular aspects, how cell mechanics that evolve over time and in space emerge as large-scale tissue dynamics (as an intrinsic force), and how cell mechanics arises from tissue dynamics and feedback to cellular and molecular function (as an extrinsic force).
To study the mechanical interactions between cells within a tissue, we detect and extract the mechanical signatures (e.g., cell adhesion, cytoskeleton, and mechanical forces) from a tissue with an interdisciplinary approach that combines imaging, quantitative analysis, gene manipulation, biophysical manipulation tools (e.g., laser ablation), and biophysical modeling.
In this presentation, I am going to cover our recent findings regarding mechanical force behind tissue morphogenesis [1-5], including an active mechanical role of programmed cell death, apoptosis.
|連絡先||知能数理研究分野 中垣俊之 佐藤勝彦|